Create Your Own Advanced ECM for 3D Cell Culture

Design over 100 possible combinations to study the biological and biophysical properties for the cell culture environment.

“Building Blocks for Tissue Engineers”
With the VitroGel High Concentration hydrogels, scientists have more ability to manipulate the biophysical and biological properties of the cell culture environment. They can investigate different combinations of VitroGel® products to find the right conditions for their experiments. For example, VitroGel RGD can be combined with other functional adhesive ligand hydrogels, such as VitroGel® COL, VitroGel® IKVAV, or VitroGel® YIGSR to form a heterogeneous and realistic microenvironment. The VitroGel® MMP, an enzyme-sensitive hydrogel, can be used to study the degradation of the local ECM by metastatic cells for invasion and dissemination into new tissue. This feature permits the examination of cellular responses in a more physiologically relevant context while still giving experimenters full control. Due to the diversity of VitroGel® High Concentrations hydrogels, a wide variety of cell types from different tissues can be tested.

over 100 possible combination

Multiple studies have made use of biofunctional hydrogel in different tissue and cell types. In nature, the microenvironment is complicated. Each single cell type can respond to different functional ligands such as RGD, Collagen, Laminin, and MMP. VitroGel hydrogel system is a powerful tool for scientists to study many cellular processes and behaviors in response to different extracellular matrix functional ligands. The table below provides a quick guideline to help customers identify the functional hydrogel that can be used for their cell types. Keep in mind many more possibilities have not been explored yet. The “mix and match” function of VitroGel gives flexibility for all possibilities.